This study aims to propose a conceptual model in the relationship between the business performance (BP) and management information system (MIS) functions, and its impact on the operational excellence (OE) in banks. The literature in this domain is reviewed and the research gaps are identified. The conceptual model is constructed based on three main variables: BP management, MIS functions, and OE. The conceptual model presents the research hypotheses that would be tested. There are limited studies on the effect of BP on OE and the mediating role of MIS in the context of banks. Thus, the contribution of this study is a presentation of the relationships between the various study variables based on a clear model. Further testing of the proposed model will be the direction of future work.