The effectiveness of human resource management (HRM) practices is critical for the overall performance of organizations. Therefore, the purpose of this study is to examine the determinants of HRM effectiveness at hospitals in UAE. Due to time and cost limitations, the study focuses on Fujairah Hospital. The population of this study consists of employees working in the hospital. A total of 100 employees participated in this study. The hypotheses were tested using regression analysis. The finding showed that there are high levels of efficiency HRM practices presented by including staffing, HR planning, compensation, training and development, and performance appraisal. The findings indicated that training and development are the most critical determinants of HRM practice effectiveness followed by compensation. Thus, there is a positive association has been determined among the effectiveness of HRM with all the functions.