Innovation is considered to be one of the key factors that influence the long term success of a company in the competitive markets of today. As a result, there is a growing interest in the further study of the determining factors of innovation. Today, the focus is on these factors related to people and behaviour, emphasizing the role of organizational culture, as a factor that can both stimulate or restrain innovation, and therefore affect company performance. However, there is little empirical research linking these variables, particularly in the Spanish context. The purpose of this paper is to study these links by using a sample of industrial companies. The results show that culture can foster innovation, as well as company performance, or it could also be an obstacle for both of them, depending on the values promoted by the culture. It has been found specifically, that an adhocratic culture is the best innovation and performance predictor. Based on these results, it can be concluded that, innovation mediates the relationship between certain types of organizational cultures and performance.